In an attempt to understand a problem researchers are often compelled to design and execute their own scientific investigations. Research compilation methods have been utilized for years, but their popularity has grown in the past few decades. The goal of this paper is to critique the systematic review procedure, known as meta-analysis.

This paper will begin with a brief history of meta-analysis to give context. Next, current methodological criticisms will be identified to display
this paper’s primary motivation. An example in the field of nutritional epidemiology will be used to illustrate these current difficulties, and give suggestions to help minimize their potentially negative effects.

Several methods were identified to mitigate some of the common biases associated with meta-analysis. These methods were prospective registration of research, comprehensive searches, and statistical plots. The example conducted in the field of Nutritional Epidemiology gave a practical application and illustrated the strength of research complication to address some of the most imperative problems of today.